A hyposalinity treatment will kill: Pods, snails, crabs, invertebrates, corals, live rock, most marine algae, and Marine Ich. This is why it is best performed in a separate, bare bottom, hospital tank. It has been performed successfully in fish only aquariums where there is no live rock and the substrate doesn't have worms and pods in it. But the best treatment tank is a bare bottom hospital tank, set up like a quarantine tank