I use a Typhoon Extreme III from air water and ice, but I have heavily modded it to include 2 extra DI stages (so has 3 DI stage in total) and an extra membrane, which makes it a 300gpd unit. Luckily I have excellent pressure at my house so I haven't needed to add a booster pump. Generally though if you add an extra membrane you need to add a booster.
The unit has a pressure gauge on it that is inline and follows the membrane stage and after the second membrane the pressure still measures 65psi which is just a little over the minimum. If it were to drop any further I would need to add a booster.
My whole system is plumbed so the waste line dumps into my front yard drip sprinkler system too. The only time I have put the waste down the drain is during the winter, but otherwise all my waste water helps water my yard.
Can't say I have ever done a deep clean on the system and I have been using it for about 10 years now. As far a filter replacements go I change out the sediment and carbon filter about every 500 gallons produced, and I change the DI in the first canister when ever the color change indicates to do so, which is about every 300-400g. The other 2 DI canisters get changed out as needed too, but as long as you keep up on the 1st DI you don't need to change the others very often.
The reason I run 3 DI stages is because my area has very high levels of silicates in the water column, likely due to old clay water pipes from the city into my house. When I ran only a single Di some of those silicates could get by the filter and ended up in my tank which caused a huge Dyno problem after it built up. Now I run 3 to make sure none of that has any chance of getting in the tank.
I think in all the years I have been running the system I have only changed the membranes twice. Membranes for the most part last for year. I check the tds before and after every time I run the system. If TDS starts to rise and all the filters have been exchanged for new ones, then that is a pretty good indicator that its time to change the membrane