Well, I have been running a deep sand bed continuously for about 12 years in my parents 135 gallon reef tank. A "deep" sand bed is anything that is typically 3-6" or deeper. At this depth you will culture 2 types of bacteria aerobic, and anaerobic. These two bacteria are integral in the fixing of ammonia into nitrite and nitrite into nitrate. Because they are aerobic (oxygen loving) or anaerobic (oxygen hating) They need to be kept separate of one another, and not stirred up. If you had a mature sand bed and mixed the anaerobic layer into the aerobic and vice versa, you are going to kill off millions of bacteria, thus causing a huge ammonia spike.
It is important to have critters that will keep the top aerobic layer stirred up, as the bacteria NEED oxygen to function, and as such, critters such as nassarius snails, gobies, stars and cukes are important to have.
Juan like I mentioned before, the issue is going to be keeping the slope shaped. It might be worthwile if you are really interested in doing this to seal a glass partition in the bottom of the tank that was say 4" tall, that way, all the sand to one side of that partition would stay put and therfore culture the bacteria you are wanting without the worry of things shifting, and as such ruining your biological filtration.
Cheers~!
Jon